dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity
نویسندگان
چکیده
منابع مشابه
Tolerogenic and Activatory Plasmacytoid Dendritic Cells in Autoimmunity
Plasmacytoid dendritic cells (pDCs) are a particular subset of DCs that link innate and adaptive immunity. They are responsible for the substantial production of type 1 interferon (IFN-I) in response to viral RNA or DNA through activation of TLR7 and 9. Furthermore, pDCs present antigens (Ag) and induce naïve T cell differentiation. It has been demonstrated that pDCs can induce immunogenic T ce...
متن کاملPredominant Role of Plasmacytoid Dendritic Cells in Stimulating Systemic Autoimmunity
Plasmacytoid dendritic cells (pDCs), which are prominent type I interferon (IFN-I)-producing immune cells, have been extensively implicated in systemic lupus erythematosus (SLE). However, whether they participate critically in lupus pathogenesis remains unknown. Recent studies using various genetic and cell type-specific ablation strategies have demonstrated that pDCs play a pivotal role in the...
متن کاملPlasmacytoid dendritic cells in angiolymphoid hyperplasia with eosinophilia
Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is characterized by irregularly-shaped blood vessels with an inflammatory infiltrate. While absent from normal skin, plasmacytoid dendritic cells (pDCs) infiltrate the skin upon injury and during several infectious, inflammatory, and neoplastic entities. In addition to providing anti-viral resistance, pDCs link the innate and adapti...
متن کاملResponse: Recipient plasmacytoid dendritic cells and graft-versus-host disease.
The issues raised by Markey et al are important and help to further clarify the role of plasmacytoid dendritic cells (pDCs) in graftversus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT).1 They found that recipient pDCs were highly sensitive to myeloablative total body irradiation (TBI) and were hardly detectable in the spleen and bone marrow 24 hours after T...
متن کاملIn vivo ablation of plasmacytoid dendritic cells inhibits autoimmunity through expansion of myeloid-derived suppressor cells.
Autoimmunity ensues upon breakdown of tolerance mechanism and priming of self-reactive T cells. Plasmacytoid dendritic cells (pDCs) constitute a unique cell subset that participates in the activation of autoreactive T cells but also has been shown to be critically involved in the induction of self-tolerance. However, their functional importance during the priming phase of an organ-specific auto...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2011
ISSN: 0105-2896
DOI: 10.1111/j.1600-065x.2011.01049.x